Since biological processes are time varying , they may be best described by time series gene expression rather than by a static gene expression analysis.
Acknowledging the nature of genes that are involved in dynamic biological processes (e.g., developmental processes, mechanisms of cell cycle regulation, etc.) has potential to provide insight into the complex associations between genes that are involved.
A two-step cluster validation approach is proposed to statistically estimate both the optimal number of clusters and to distinguish significant clusters from noise.
The resulting clusters reveal coordinated coexpressed genes.
Microarray and next-generation sequencing (RNA-seq) technologies enable researchers to study any genomewide transcriptome at coordinated and varying stages.Biomedicine is a field rich in knowledge, with numerous incentives to formally encode it in an electronic format and share it through usually open and community-maintained data and knowledge bases.Containing information on sequence and sequence structure, gene and protein interactions, function annotation and ontologies, or genetic and metabolic pathways.One of our major tasks is to advance data analysis and integration capabilities in genomic expression pattern discovery and classification.It has consisted of the implementation of algorithms and tools to organise and categorise genome expression data.To ensure the availability of the Digital Library we can not allow these types of requests to continue.The restriction will be removed automatically once this activity stops. This information can significantly complement any data analysis and improve its results.The inclusion of additional knowledge sources in the data analysis process can prevent the discovery of the obvious, complement a data-inferred hypothesis with references to already proposed relations, help analysis to avoid overconfident predictions and, finally, allow us to systematically relate the analysis findings to present knowledge. but we have temporarily restricted your access to the Digital Library.Your activity appears to be coming from some type of automated process.